Lakewood Ranch (LWR), the Academy for Brain Health and Performance, and Massachusetts General Hospital, a Harvard Medical School Teaching Hospital (Mass General), have partnered to design a one-of-a-kind, large-scale effort to address brain health called the Brain Health Initiative at Lakewood Ranch. The initiative proposes the most extensive, long-term brain health study ever conducted, and the Brain Health Innovation Lab, a first-of-its-kind hub for breakthrough science in brain health innovation. The initiative seeks to develop interventions and validate and test the feasibility of innovations to enhance brain health, as well as optimize performance across the lifespan. Multi-generational, community-based research will follow Lakewood Ranch residents for decades to identify factors associated with brain health and performance across the lifespan. The research will be used by a global team of researchers, neuro-technologists, engineers, innovators, entrepreneurs, and investors to discern, develop, and implement interventions aimed at optimizing brain health and performance. This collaboration will be based in the planned Brain Health Innovation Lab at CORE at Lakewood Ranch. The outcomes developed by the initiative are intended to be replicated and scaled globally.